The PEPR projects are grouped under 4 main axes:

Axis 1 – Anticipate the scale-up of cell therapies and the emergence of tissue therapies

Axis 2 – Accelerate the deployment of gene therapies

Axis 3 – Engineering to benefit biotherapies and bioprocesses

Axis 4 – Support an emerging industrial sector centered around the use of extracellular vesicles

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COBRAS

Corneal bioimpression for advanced surgical reparation

15 April 2026

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MUSCLE

Medication using specialized cell‐targeted lipid nanoparticle encapsulation in neuromuscular disorders

15 April 2026

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HIBAL

Hybrid iPSC bioartificial liver

15 April 2026

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OPTICELL

Bioengineered stem cell-derived retinal cells and tissue for cell therapy

15 April 2026

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PARADIGM

Personalised phage therapy against gram-negative multidrug resIstant organisms

15 April 2026

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REPLIBIO

New Autonomously Replicating Non-Viral Vectors

15 April 2026

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ACCREDIA

ACCelerating Research for Early Development of Innovative Antibodies

15 April 2026

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BACTER-EV-BOOSTER

Multidisciplinary approach to stimulate the bioproduction and engineering of Gram+ bacteria’s Extracellular Vesicles (EVs) for therapeutic applications to treat inflammation

15 April 2026

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Bioengineered Skin-France

Bioengineering of next-generation skin substitutes for cutaneous regeneration

15 April 2026

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BIOSCALE

Improving the whole chain of large scale AAV bioproduction through disruptive technologies

15 April 2026

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CARN

Development of biotherapies based on the local delivery of therapeutic RNAs by hybrid functionalized extracellular vesicles (EVs) for musculoskeletal regeneration

15 April 2026

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EDITO

Development of breakthrough technologies in gene editing

15 April 2026

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iCHONDRO

Generation of iChondrocytes to regenerate articular cartilage

15 April 2026

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iPSC France

Genomic editing of stable universal pluripotent stem cells for allogeneic cell biotherapies

15 April 2026

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QualAAV

Innovative approaches for quality control to support the industrial deployment of future gene therapy products.

15 April 2026

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RNAvac

New generation of mRNA-based vaccines

15 April 2026

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STROMAEV

From engineering of iPS-derived mesenchymal stromal cell-derived extracellular vesicles to clinical translation

15 April 2026

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THERA-B

B-cell genetic engineering for new therapeutic and vaccine modalities

15 April 2026

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